Pernicious anemia is an autoimmune disease that targets gastric parietal cells, resulting in gastritis, vitamin B12 (cyanocobalamin) deficiency, and a megaloblastic anemia. In this condition, autoantibodies also inhibit vitamin B12 absorption.

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Autoimmune gastritis (AG) is a corpus-restricted chronic atrophic gastritis associated with intrinsic factor deficiency, either with or without pernicious anemia. Autoimmune gastritis is a microscopic disease because patients present with no or vague symptoms, and clinicians rarely find endoscopic changes. Pernicious anaemia (PA) and chronic atrophic gastritis (CAG) aggregate in families, occur more often in women, and are associated with various heritable traits such as fair skin and blue eyes. They are linked to certain HLA types. Linkages are relatively weak for A and B antigens, but somewhat stronger in the case of DR antigens. 2016-11-28 · People with vitamin B 12 deficiency are at risk for pernicious anemia, a condition in which the body does not have enough healthy red blood cells. Autoimmune atrophic gastritis is considered a "precancerous" condition and it may be responsible for the development of gastric adenocarcinoma or carcinoids.

In rare cases, pernicious anemia is passed down through families. Autoimmune gastritis (AIG) is a gastric pathologic condition affecting the mucosa of the fundus and the body and eventually leading to hypo-achlorhydria.

2020-07-09 · Autoimmune gastritis (AIG) is an increasingly prevalent, organ-specific, immune-mediated disorder characterized by the destruction of gastric parietal cells, leading to the loss of intrinsic factor

There are also other conditions resulting in poor absorbtion or low vitamin B12. Vitamin B12 Deficiency Due to Autoimmune Gastritis Pernicious anemia is the result of advanced autoimmune gastritis, which in its initial stages is an asymptomatic autoimmune disease. First reported by Addison in 1849, the link between the anemia and gastric degeneration was realized by Flint in 1860 and histologic evidence of the gastric atrophy was provided by Fenwick in 1870. Common causes of pernicious anemia include: Weakened stomach lining (atrophic gastritis) An autoimmune condition in which the body's immune system attacks the actual intrinsic factor protein or the cells in the lining of your stomach that make it. In rare cases, pernicious anemia is passed down through families.

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minimizes their chances of being prone to allergies and other autoimmune diseases like Many people confuse gastritis with ulcers, but it is exactly the opposite.
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May 25, 2017 Anemia, Gastritis, Glossitis, Helicobacter pylori, Vitiligo. Introduction. Autoimmune gastritis (AIG) is a chronic inflammatory

May 25, 2017 Anemia, Gastritis, Glossitis, Helicobacter pylori, Vitiligo. Introduction.

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2016-08-02 · Autoimmune gastritis (AG) is a chronic disease occurring in up to 8% of the general population. This condition is characterized by loss of the oxyntic glands with consequent hypochlorhydria, lack of intrinsic factor production, and, in a later stage, pernicious anemia.

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Pernicious anemia can be treated with injections of vitamin B 12. If the symptoms are severe, injections are typically recommended initially. For those who have trouble swallowing pills, a nasal spray is available. Often, treatment is lifelong. Pernicious anemia due to autoimmune problems occurs in about one per 1000 people.

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